Single-chain factor XII
نویسندگان
چکیده
منابع مشابه
Single-chain factor XII exhibits activity when complexed to polyphosphate.
BACKGROUND The mechanism underpinning factor XII autoactivation was originally characterized with non-physiological surfaces, such as dextran sulfate (DS), ellagic acid, and kaolin. Several 'natural' anionic activating surfaces, such as platelet polyphosphate (polyP), have now been identified. OBJECTIVE To analyze the autoactivation of FXII by polyP of a similar length to that found in platel...
متن کاملFactor XII Deficiency
Factor XII ia a single-chain beta-globulin serine protease with a molecular weight of 80,000 84,000 daltons and a plasma concentration of approximately 30 pg/mL. Proteolytic cleavage of factor XII is mediated by charged surfaces (glass, kaolin, cellite, dextran sulfate, endotoxin, urates, crude collagen, sulfatides), autoactivation, and kallikrein. Prekallikrein, factor XI, factor VII, plasmino...
متن کاملActivation of factor XII by dextran sulfate: the basis for an assay of factor XII.
A system was developed for studying the activation of factor XII (Hageman factor) in the presence of dextran sulfate (DS). Salient features of the system included low ionic strength (0.08), low concentration of factor XII (approximately 1/10,000 that in normal plasma), and an excess of exogenous prekallikrein (PK). In this system, factor XII was rapidly converted to the 80,000 molecular weight ...
متن کاملFactor XII Osaka: abnormal factor XII with partially defective prekallikrein cleavage activity.
A healthy Japanese male had reduced factor XII (FXII) activity (35%) in contrast to normal antigen levels (81%). The F12 of this proband had a 9775G to C mutation in exon 10 and an 11276G to A mutation in exon 13 that resulted in two amino acid substitutions of Ala324Pro (GCG→CCG) in the proline-rich connecting region and Gly531Glu (GGG→GAG) near the active Ser544 in the catalytic domain. His f...
متن کاملCharacterization of factor XII Tenri, a rare CRM-negative factor XII deficiency.
Factor XII Tenri (Y34C), a rare cross-reacting material (CRM)-negative factor XII deficiency, was identified in a 71-yr-old Japanese woman with angina pectoris. In the patient's plasma, factor XII activity and antigen levels were only 1.6% and 5.0%, respectively, of those seen in a normal subject. Immunoblot analysis showed that the secreted factor XII Tenri existed not only as a monomer (76 kD...
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ژورنال
عنوان ژورنال: Current Opinion in Hematology
سال: 2017
ISSN: 1065-6251
DOI: 10.1097/moh.0000000000000363